Aug 1, 2014
             
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      Updated: Aug 1, 2014 
AUTONOMY: Comparison of two patient-driven approaches for initiating and titrating prandial insulin lispro in type 2 diabetes   
Prandial insulin lispro can effectively and safely be initiated, by either of two self-titrated algorithms, in a variety of practice settings.
HARMONY 3: Efficacy and safety of albiglutide versus placebo, sitagliptin, and glimepiride in T2DM patients on metformin   
Albiglutide when added to metformin produces superior reductions in HbA1c and FPG at week 104 when compared with placebo, sitagliptin, and glimepiride.
AWARD-5: Efficacy and safety of dulaglutide versus sitagliptin in type 2 diabetes   
Both dulaglutide doses confer superior glycemic control versus sitagliptin with an acceptable tolerability and safety profile.
Efficacy and safety of dulaglutide added onto pioglitazone and metformin versus exenatide in patients with T2DM   
Both once-weekly dulaglutide has superior outcomes on glycemic control, over placebo and exenatide.
ADVANCE Trial: Role of cardiac biomarkers N-terminal pro–B-type natriuretic peptide and high-sensitivity troponin T in predicting microvascular events in T2DM patients   
Cardiac biomarkers moderately improve prediction of microvascular event risk, particularly the risk of nephropathy.
     
Outcomes of trimetazidine treatment in diabetic patients with renal dysfunction undergoing elective percutaneous coronary intervention   
Trimetazidine intake before elective PCI in diabetic patients with mild-to-moderate renal dysfunction is associated with decreased incidence of CIN and myocardial injury.
AWARD-5: Dose-finding results of once-weekly dulaglutide combined with metformin in patients with type 2 diabetes   
Greatest placebo-adjusted mean change in DBP was recorded with Dulaglutide 1.5 mg while greatest placebo-adjusted mean change in weight is associated with Dulaglutide 2.0 mg treatment.
Impact of metformin on cancer patients with concurrent diabetes   
Metformin improves the survival for cancer patients with concurrent diabetes, particularly for breast, colorectal, ovarian, and endometrial cancer.
Influence of sitagliptin on atherosclerosis-related cardiovascular diseases in newly diagnosed with impaired glucose tolerance or mild type 2 diabetes mellitus   
Sitagliptin for 12 months was associated with a beneficial effect in the prevention of carotid IMT progression, compared with the diet control.
CASPIAN III Study:Obesity in identifying cardiometabolic risk factors among children and adolescents   
Combined type of generalized and abdominal obesity is a predictor of cardiometabolic risk factors.
Retrobulbar blood flow velocities in diabetic patients without or with retinopathy   
There are significant changes in retrobulbar blood flow in eyes without and with diabetic retinopathy.
Distribution of intraretinal exudates in diabetic macular edema undergoing anti-vascular endothelial growth factor therapy   
During intravitreal anti-vascular endothelial growth factor therapy, diabetic macular edema reduction was accompanied by dynamic rearrangement of intraretinal exudates at corresponding locations in fundus photography and SD-OCT.
Obstructive sleep apnea in poor responders to bevacizumab pharmacotherapy in age-related macular degeneration and in diabetic macular edema   
Risk of OSA is significantly higher in patients with exudative AMD and diabetic macular edema with poor response to anti-vascular endothelial growth factor therapy.
Outcomes of combined tractional and rhegmatogenous retinal detachment in proliferative diabetic retinopathy in the era of Anti-VEGF   
Poor visual outcomes are predicted by poor preoperative visual acuity and severe proliferations.
DPV Registry: Use of insulin analogues detemir and glulisine in overweight/obese subjects   
Detemir is more frequently used in overweight and obese patients compared to normal-weight patients.
Impact of NPH insulin, insulin detemir and insulin glargine on the GH - IGF-I - IGFBP axis in T1DM patients   
A single dose of detemir leads to larger suppression in serum IGFBP-1, when compared to NPH and glargine.
Correlation of diabetes and anti-diabetic medications with clinical outcomes in multiple myeloma   
Insulin/analogues administration leads to poor outcomes, while metformin administration improves outcomes.
OpT2mise: Insulin pump treatment versus multiple daily injections for treatment of type 2 diabetes   
Multiple daily injections of insulin, pump treatment can be considered as a safe and valuable treatment option in patients with poorly controlled type 2 diabetes.
Correlation between between prehypertension, metabolic and inflammatory markers, decreased adiponectin and enhanced insulinemia in obese subjects   
Higher glycemic and elevated blood pressure levels are reported in a hyperinsulinemic subgroup of well-characterized metabolic syndrome bearers-obese subjects versus lean and normoinsulinemic subjects.
Association of skin autofluorescence with vascular calcification in chronic kidney disease   
Increased tissue advanced glycation end product may contribute to vascular calcification in chronic kidney disease and diabetes mellitus.
Relation between adiponectin level and vascular complications in children with T1DM   
High adiponectin correlate with the presence of microvascular disease but does not offer protection against cardiovascular disease in children with type 1 diabetes.
Association of preoperative glucose optimization prior to a Roux-en-Y gastric bypass and diabetes remission in T2DM patients   
A greater degree of glycemic improvement in response to presurgical medical intervention is associated with higher rates of diabetes remission post-operatively among obese T2DM adults.
Efficacy and safety of albiglutide versus sitagliptin in patients with type 2 diabetes and renal impairment   
Albiglutide therapy once-weekly provides statistically superior glycemic improvement with almost similar tolerability compared with daily sitagliptin therapy in T2DM patients with renal impairment.
Correlation between diabetes, antidiabetic medications and pancreatic cancer risk   
Diabetes plays a causal role in pancreatic cancer.
Impact of increasing oral loads of glucose and corresponding isoglycaemic intravenous glucose infusions on glucagon responses in T2DM patients and healthy individuals   
Hyperglucagonaemic response to oral glucose in type 2 diabetes may represent a pathological version of a gut-derived physiological phenomenon.
Diabetes as risk factor for incident coronary heart disease vary according to gender   
Women with diabetes have more than a 40% greater risk of incident CHD compared with men with diabetes.
Abdominal obesity: a causal factor or a symptom of obesity-related health risk   
Abdominal fat reduction alone is not directly linked to improvement in obesity-related health risk factors.
Insulin detemir versus insulin glargine in patients with type 2 diabetes mellitus   
Initiation of basal insulin analogues, IDet and IGlar, clinically and significantly improved glycaemic control.
JDCS analysis: Correlation between dietary sodium intake and incidence of diabetes complications in patients with type 2 diabetes   
High dietary sodium intake is associated with elevated incidence of CVD in patients with type 2 diabete.
Efficacy and safety of add on therapy of colesevelam to pioglitazone in patients with type 2 diabetes mellitus   
add-on colesevelam therapy improved glycemic control and lipid parameters in T2DM subjects inadequately controlled with pioglitazone-based therapy.
Metabolic disorders most commonly associated with nonalcoholic fatty liver disease   
Triglyceride is strongly associated with nonalcoholic fatty liver disease among markers of hyperlipidemia and diabetes.
Effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 on glucagon responses to insulin-induced hypoglycemia in T1DM patient   
Glucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycemia in type 1 diabetes.
Role of dyslipidemia in controlling arterial hypertension in T2DM   
Dyslipidemia significantly influences the control of blood pressure in T2DM patients.
Laparoscopic Roux-en-Y Gastric Bypass for type 2 diabetes mellitus among the nonobese   
Laparoscopic Roux-en-Y gastric bypass surgery leads to significant weight loss and remission of T2DM.
Correlation of pentraxin 3 with coronary atherosclerosis and metabolic factors   
Pentraxin 3 may have an atheroprotective role and may serve as a simple biomarker, like adiponectin.
Impact of short bouts of high-intensity resistance-style training on fasting blood glucose of diabetic offspring   
High-intensity-resistance-focused training is effective for improving fasting glucose in family history of diabetics.
Endogenous incretin hormone augmentation of acute insulin secretion in normoglycaemic relatives of T2DM subjects   
Incretin hormone action on acute insulin release is maintained in normoglycaemic relatives and control subjects over 10y.
Concentrations of betatrophin in human obesity and type 2 diabetes   
Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes.
Impact of vagal nerve blockade using electrical impulses on glucose metabolism among nondiabetic individuals   
Electrical vagal blockade has no acute effects on glucose metabolism, insulin secretion and action, or gastric emptying in nondiabetic subjects.
Correlation between pioglitazone and risk of kidney cancer   
Pioglitazone does not affect the risk of kidney cancer in patients with type 2 diabetes
Metabolic and cardiovascular risk factors in the polycystic ovary syndrome   
Multiple correlated variables from patients with PCOS were insulin resistance, dyslipidaemia/hypertension and hyperandrogenaemia
Mechanism of glucose lowering effect of canagliflozin in T2DM patients   
Canagliflozin reduces post-meal glucose excursion in patients with type 2 diabetes by a non-renal mechanism
Corneal nerve fiber length reduction in patients with type 1 or type 2 diabetes mellitus   
The extent of corneal nerve damage maybe influenced by type of diabetes and degree of neuropathy.
Correlation between diabetes, diabetes treatment and risk of developing endometrial cancer   
Metformin is was not significantly associated with endometrial cancer risk
Additive effect of cigarette smoking on the risk of systemic inflammation in metabolic syndrome   
Cigarette smoking worsens systemic inflammation in persons with metabolic syndrome.
Dapagliflozin versus existing anti-diabetes treatments for type 2 diabetes mellitus patients inadequately controlled on sulfonylurea monotherapy   
Dapagliflozin as add-on therapy provides both a favourable weight and hypoglycaemia profile.
Association of skin microcirculation with HbA1c and the incidence of ischaemic foot ulcer in T1DM   
Improved glycaemic control in T1DM patients is associated with an improvement in skin microcirculation and with a lower incidence of ischaemic foot ulcers.
Posterior interosseous nerve of diabetic and non-diabetic patients with carpal tunnel syndrome   
There is increased nerve fibre and microvascular pathology in relation to enhanced expression of VEGF and its receptors in a non-compressed nerve in diabetic versus non-diabetic patients with CTS.
Role of the inflammatory pathway and complement C3 in hypofibrinolysis in type 2 diabetes   
C3 plasma levels are independently associated with fibrin clot lysis in T2DM patients.
Impact of bariatric surgery with sleeve gastrectomy vs. gastric bypass on ventricular remodelling   
Bariatric surgery has an important effect in reverse left ventricular and right ventricular remodelling.
Correlation between DASH diet, insulin resistance and inflammation in polycystic ovary syndrome   
DASH eating pattern for 8 weeks improves insulin resistance, serum hs-CRP levels and abdominal fat accumulation in overweight and obese women with PCOS.
Anti-VEGF versus laser photocoagulation for treating visual impairment due to diabetic macular edema   
Ranibizumab was non-significantly superior to aflibercept and both anti-VEGF therapies had statistically superior efficacy to laser.
Responses of retinal vessels to flickering light in diabetic patients with various stages of diabetic retinopathy   
Responses of retinal arterioles and venules to flickering light are reduced in subjects with DR, and decrease progressively with more severe stages of DR.
PRO.V.A. Study: Correlation between serum 25-hydroxyvitamin D and incidence of diabetes in the elderly   
Baseline serum concentrations of 25OHD were not associated with the incidence of diabetes in community-dwelling elderly people.
Impact of bacterial product translocation on clinical outcomes of morbid obese patients undergoing bariatric surgery   
Bacterial DNA translocation holds increased insulin resistance and systemic inflammatory levels in morbid obese patients.
Association of below-knee arterial calcification with receptor activator of nuclear factor kappa B ligand, osteoprotegerin and neuropathy in type 2 diabetes   
Below knee arterial calcification severity was correlated with peripheral neuropathy severity and with several usual cardio-vascular risk factors, but not with serum RANKL level.
Correlation of platelet volume indices with macrovascular and peripheral neuropathy complications in patients with T2DM   
Both mean platelet volume and platelet distribution width are significantly associated with vibration perception threshold.
Clinical characteristics and phenotype–genotype analysis of patients with congenital hyperinsulinism   
Mutations in ABCC8 and KCNJ11 are the commonest causes of congenital hyperinsulinism.
Cross-sectional and longitudinal relation of IGF1 and IGF-binding protein 3 with lipid metabolism   
There is no influence of baseline IGF1 or IGFBP3 serum concentration on incidentally elevated or reduced lipid levels.
Impact of trimetazidine on contrast-induced nephropathy in diabetic patients with renal dysfunction undergoing elective percutaneous coronary intervention   
Trimetazidine intake before elective PCI is associated with decreased incidence of contrast-induced nephropathy and myocardial injury in diabetic patients with mild-to-moderate renal dysfunction.
Metabolic syndrome in children  
The Harmonious Efficacy of Albiglutide as an Add-On therapy or Monotherapy for an Individualized T2DM Management  
Canagliflozin: The Blockbuster drug for the Co-morbid T2DM treatment  
Dapagliflozin: Clinical perspective   
Treatment and management of diabetic macular edema   
Gestational diabetes mellitus   
From trivial to extremely vital - The resurrection of Metabolic Syndrome for the present Diabetes management  
Lifestyle counseling in routine patient care  
  More..     
 

     

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EASD - European Association for the Study of Diabetes, 2014
Sep 15, 2014 - Sep 19, 2014.
Vienna, Austria


    

 


 
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