Sep 17, 2014
             
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      Updated: Sep 17, 2014 
Role of Liraglutide in the Fixed-Ratio Combination of Insulin Degludec and Liraglutide   
IDegLira is superior to IDeg in achieving glycemic control, at equivalent insulin doses without higher risk of hypoglycemia and with the benefit of weight loss.
Pharmacokinetics and pharmacodynamics of a new insulin glargine comprising 300 units•mL−1 versus insulin glargine 100 units•mL−1   
New insulin glargine 300 units•ml−1provides a more even activity profile and prolonged glycemic control at steady state compared with insulin glargine 100 units•ml−1.
Incidence of diabetes in prediabetic men who achieved normal glucose tolerance   
Early improvement predicts reduced risk of incident diabetes and improved cardiovascular risk in prediabetic men.
Correlation between HDL cholesterol and cancer risk in T2DM patients   
HDL-C was inversely associated with cancer risk among men and women with type 2 diabetes.
     
SAVOR - TIMI 53: Correlation between heart failure, saxagliptin and diabetes mellitus   
Saxagliptin is associated with an increased risk for hospitalization for heart failure.
FU-Registry: Associations between hypoglycemic agents and clinical outcome of percutaneous coronary intervention among diabetics   
Of the hypoglycemic agents, insulin is associated with poor mid-term clinical outcomes in DM patients who underwent PCI, while BG is negatively correlated with MACEs.
The Singapore Chinese Health Study: Correlation between glycated hemoglobin, all-cause, and cause-specific mortality in patients without diagnosed diabetes   
HbA1c levels consistent with undiagnosed type 2 diabetes (≥6.5%) are associated with an increased risk of all-cause and cause-specific mortality.
Greater Dose-Ranging Effects of LX4211 on A1C Levels and Glucosuria in Type 2 Diabetes patients on Metformin Monotherapy   
Dual inhibition of SGLT1/SGLT2 with LX4211 results in significant dose-ranging improvements in glucose control with no dose-increasing glucosuria.
Metabolic Control from Childhood to Young Adulthood in Type 1 Diabetes   
Pre-pubertal HbA1c is a significant and relevant predictor of metabolic control in young adulthood.
Impact of n-3 FA therapy on triglycerides and flow-mediated dilation in patients with hypertriglyceridemia   
Omega-3 fatty acid therapy dose-dependently and significantly decreased triglycerides and improved flow-mediated dilation, however, did not significantly improve insulin sensitivity in patients with hypertriglyceridemia.
Prevalence of carbohydrate metabolism disorders in patients who receive total parenteral nutrition   
Very high prevalence of carbohydrate metabolism disorders in noncritically ill patients on total parenteral nutrition affect insulin treatment and the degree of metabolic control achieved.
Association of reduced heart rate variability with pre-clinical cardiovascular disease in T2DM patients   
SDNN and SDANN are associated with left ventricular hypertrophy and aortic stiffness.
Long-term follow-up after bariatric surgery in cohorts with adequate retention rates   
gastric bypass has better outcomes than gastric band procedures with respect to long-term weight loss, type 2 diabetes control and remission, hypertension, and hyperlipidemi.
Heart and Soul Study: Effect of physical activity level on biomarkers of inflammation and insulin resistance in coronary heart disease   
Higher physical activity frequency is independently associated with lower levels of CRP, interleukin-6, and glucose, in outpatients with known CHD.
Efficacy and safety of saxagliptin in patients with type 2 diabetes receiving concomitant statin therapy   
Saxagliptin improves glycemic control and is generally well tolerated in patients with T2DM, irrespective of concomitant statin therapy.
Effect of hyperglycemia and disease duration on cardiac autonomic dysfunction in type 2 diabetes   
Elevated blood glucose levels have an unfavorable effect on cardiac autonomic function, which is pronounced in long-term T2DM patients.
DDCRT7: Diabetes Distress and Care Registry at Tenri   
Serum high-sensitivity C-reactive protein levels are associated with high risk of development, not progression, of diabetic nephropathy among T2DM patients.
Managing T2DM patients with hospital discharge algorithm based on admission HbA1c   
HbA1c measurement on admission is beneficial in tailoring treatment regimens at discharge in general medicine and surgery patients with type 2 diabetes.
Glucagon-like peptide 1 receptor agonist versus bolus insulin with optimized basal insulin in type 2 diabetes   
Adding exenatide to titrated glargine with metformin leads to similar glycemic control as adding lispro.
Correlation between sulfonylurea use and incident cardiovascular disease among women with type 2 diabetes   
Sulfonylureas when used for long term were associated with a significantly higher risk of developing CHD among women with diabetes.
Impact of of intensification or initiation of insulin treatment with biphasic insulin 50/50   
Obesity independently predicts responders to biphasic insulin 50/50 (Humalog Mix50 and Insuman Comb 50) following conversion from other insulin regimens.
Effect of statins on the uptake of glucose analogs by human cells   
Statins significantly inhibited the uptake of glucose analogs in human cells.
Efficacy and safety of linagliptin in inadequately controlled T2DM patients   
Linagliptin administration leads to clinically meaningful improvement in glycemic control without weight gain or increased risk of hypoglycemia.
Identifying adults with normal glucose tolerance but increased risk of non-alcoholic fatty liver disease   
Value of a 1-hour OGTT glucose ≥155 mg/dL may be helpful in identifying a subset of normal glucose tolerance individuals at risk for non-alcoholic fatty liver disease.
Interleukin 6 gene expression in circulating mononuclear leukocytes of dyslipidemic patients with protective HDL-C levels   
Protective HDL-C levels in patients with dyslipidemia are intimately associated with a decreased expression of IL6 in peripheral blood mononuclear cells, even after adjustments in relevant confounding factors.
SUMO: Feasibility and accuracy of stress ultrasonography in morbid obesity   
Stress echocardiography, a widely available, safe and accurate technique, can be used to detect inducible ischemia in morbidly obese patients.
Correlation between coronary flow reserve and contractile reserve in T2DM patients with normal coronary angiography   
Reduction of Dip-stress derived longitudinal function when it is still normal at rest, represents an early marker of myocardial dysfunction in DM.
Association of diabetic retinopathy with subclinical myocardial dysfunction in T2DM patients   
Microvascular dysfunction contributes to both resting and stress myocardial dysfunction in T2DM patients.
Body mass index and visceral adipose tissue together act as predictors of cardiovascular risk factors and outcomes   
Body mass index and visceral adipose tissue together act as predictors of cardiovascular risk factors and outcomes.
Impact of childhood body weight on the risk of hypertension   
Obese youngsters have a risk of hypertension which is six times greater than that observed in normal weights.
ADVANCE-ON: Long term effects of blood pressure lowering in patients with type 2 diabetes   
Reductions in all-cause death and cardiovascular death recorded during active treatment are sustained to the end of post-trial follow-up, but are diminished.
Risk factor for contrast-induced nephropathy after percutaneous coronary intervention   
Metabolic syndrome is a risk factor for contrast-induced nephropathy after percutaneous coronary intervention.
ODYSSEY COMBO II: Alirocumab outshines ezetimibe for lowering cholesterol   
Alirocumab significantly improved cholesterol levels compared to ezetimibe, when added to regular statin therapy in patients with high cholesterol and elevated risk of cardiovascular disease (CVD).
ODYSSEY FHI & II: Alirocumab shows lipid-lowering promise in patients with heterozygous familial hypercholesterolaemia   
An investigational lipid-lowering agent called alirocumab produced superior results compared to placebo.
LISTEN: Rosuvastatin versus atorvastatin in lowering cholesterol in T2DM patients   
Rosuvastatin may be a better choice than atorvastatin as cholesterol-lowering statin medications for patients with type 2 diabetes.
Hybrid coronary revascularization versus coronary artery bypass surgery in patients with diabetes mellitus   
When compared to the conventional CABG surgery, hybrid coronary revascularization is associated with less blood product usage and faster recovery.
EURIPE: Glycemic control for kidney injury prevention after PCI   
There is an absolute and percentage significant reduction of serum creatinine after PCI in patients with GIK infusion and NAC administration, in addition to ISS.
Impact of statin therapy on low-density lipoprotein cholesterol and triglyceride levels in patients with hypertriglyceridaemia: A VOYAGER meta-analysis   
LDL-C reduction is substantial and dependent on the choice and dose of statin, in patients with hypertriglyceridemia.
Preventing contrast-induced nephropathy in diabetic patients with chronic kidney disease undergoing coronary interventions   
Single dose administration of erythropoietin prior to coronary angiography or PCI results in trend toward reduction in the incidence of contrast-induced nephropathy.
SMART-MR Study: Correlation between metabolic syndrome, prediabetes, and brain abnormalities in patients with manifest arterial disease   
There exists an association of presence of MetS with smaller brain volume, in patients with manifest arterial disease and even in patients without diabetes.
Impact of metformin versus other antidiabetes medications on risk of cancer   
Diabetics who use metformin have similar risk of developing cancer as those who use sulfonylureas.
Associations of diabetes with β-cell dysfunction and insulin resistance in obese and nonobese women with prior gestational diabetes mellitus   
Among women with prior GDM, β-cell dysfunction show more pronounced contribution to postpartum diabetes in nonobese subjects, while insulin resistance contribute more towards postpartum hyperglycemia among obese subjects.
Boston Puerto Rican Health Study: Association of food-insecure dietary patterns with longitudinal glycemic control in diabetes   
Food insecurity is associated with poor longitudinal glycemic control in diabetes.
Role of osteopontin in complications experienced by patients with type 1 diabetes   
Osteopontin is a strong predictor of incipient diabetic nephropathy, cardiovascular disease, and all-cause mortality in T1DM patients.
Impact of exenatide, sitagliptin, or glimepiride on secretory capacity of β-cell in early type 2 diabetes   
Exenatide or sitagliptin treatment has no significant effect on functional β-cell mass while glimepiride appears to enhance β- and α-cell secretion.
Association of neurocognitive functioning at the time of diagnosis of T1DM with glycemic control after 1 year of diagnosis in children and adolescents   
Deficits in neurocognitive functioning within days of diabetes diagnosis that are associated with diabetes outcomes over 1 year post-diagnosis.
Is the presence of microangiopathy conditional to the development of hyperglycemia-related cerebral compromise   
Ventral striatum, but not cortical volume loss, is related to cognitive dysfunction in T1DM patients with and without microangiopathy.
MAXWEL-CAD Study: Association of rate of weight gain during early adulthood with prevalence of subclinical coronary artery disease in recently diagnosed type 2 diabetes   
Greater rate of prior weight gain may accelerate the subclinical vascular complications development in patients with newly diagnosed T2D.
Impact of telmisartan versus active controls on insulin resistance in hypertensive patients   
Telmisartan significantly improves insulin resistance in patients with hypertension.
Impact of individual mindfulness-based cognitive therapy and cognitive behavior on depressive symptoms among diabetics   
Mindfulness-based cognitive therapy and cognitive behavior therapy individually improve a range of psychological symptoms effectively, in individuals with type 1 and type 2 diabetes.
SAVOR-TIMI 53: Incidence of pancreatitis and pancreatic cancer with saxagliptin   
Risk for pancreatitis in type 2 diabetic patients treated with saxagliptin is low.
St. Carlos Gestational Diabetes Study: Impact of IADPSG criteria for the screening and diagnosis of gestational diabetes mellitus on pregnancy outcomes   
Application of the new IADPSGC is associated with a 3.5-fold increase in prevalence of GDM and also significant improvements in pregnancy outcomes.
Association of Dipeptidyl Peptidase - 4 inhibitors with risk of fracture in type 2 diabetes mellitus patients   
Dipeptidyl Peptidase - 4 inhibitors is not associated with fracture risk fracture compared to controls and to other NIAD users.
Action to Control Cardiovascular Risk in Diabetes Study: Impact of glycemic control on incident atrial fibrillation and outcomes   
Intensive glycemic control does not have any affect on the rate of new-onset atrial fibrillation.
The effect of hyperbaric oxygen therapy on ischemia-modified albumin levels in people with diabetes with foot ulcers   
There is no change in ischemia-modified albumin levels with hyperbaric oxygen therapy in patients with diabetic foot ulcers.
Outcomes of teneligliptin, as an add on treatment in T2DM patients on insulin therapy, with or without other antidiabetes agents   
Add-on treatment with teneligliptin ameliorates glucose fluctuations and improves glycemic control index in patients with type 2 diabetes on insulin therapy.
Malmo preventive project:Correlation between fasting plasma insulin and atrial fibrillation in men   
High levels of fasting plasma insulin are associated with lower risk of incident AF in a middle-aged population.
Association of metabolic syndrome with coronary artery disease based on the presence of diabetes in a symptomatic population   
MetS was independently associated with the presence and severity of CAD only in the non-diabetic subjects.
Efficacy and safety of canagliflozin in T2DM patients   
Canagliflozin improves reduction in glycated hemoglobin A1c levels and body weight with low risk of hypoglycemia.
Metabolic syndrome in children  
The Harmonious Efficacy of Albiglutide as an Add-On therapy or Monotherapy for an Individualized T2DM Management  
Canagliflozin: The Blockbuster drug for the Co-morbid T2DM treatment  
Dapagliflozin: Clinical perspective   
Treatment and management of diabetic macular edema   
Gestational diabetes mellitus   
From trivial to extremely vital - The resurrection of Metabolic Syndrome for the present Diabetes management  
Lifestyle counseling in routine patient care  
  More..     
 

     

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