Jul 22, 2014
             
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      Updated: Jul 22, 2014 
Impact of bariatric surgery with sleeve gastrectomy vs. gastric bypass on ventricular remodelling   
Bariatric surgery has an important effect in reverse left ventricular and right ventricular remodelling.
Correlation between DASH diet, insulin resistance and inflammation in polycystic ovary syndrome   
DASH eating pattern for 8 weeks improves insulin resistance, serum hs-CRP levels and abdominal fat accumulation in overweight and obese women with PCOS.
Anti-VEGF versus laser photocoagulation for treating visual impairment due to diabetic macular edema   
Ranibizumab was non-significantly superior to aflibercept and both anti-VEGF therapies had statistically superior efficacy to laser.
Responses of retinal vessels to flickering light in diabetic patients with various stages of diabetic retinopathy   
Responses of retinal arterioles and venules to flickering light are reduced in subjects with DR, and decrease progressively with more severe stages of DR.
     
PRO.V.A. Study: Correlation between serum 25-hydroxyvitamin D and incidence of diabetes in the elderly   
Baseline serum concentrations of 25OHD were not associated with the incidence of diabetes in community-dwelling elderly people.
Impact of bacterial product translocation on clinical outcomes of morbid obese patients undergoing bariatric surgery   
Bacterial DNA translocation holds increased insulin resistance and systemic inflammatory levels in morbid obese patients.
Association of below-knee arterial calcification with receptor activator of nuclear factor kappa B ligand, osteoprotegerin and neuropathy in type 2 diabetes   
Below knee arterial calcification severity was correlated with peripheral neuropathy severity and with several usual cardio-vascular risk factors, but not with serum RANKL level.
Correlation of platelet volume indices with macrovascular and peripheral neuropathy complications in patients with T2DM   
Both mean platelet volume and platelet distribution width are significantly associated with vibration perception threshold.
Clinical characteristics and phenotype–genotype analysis of patients with congenital hyperinsulinism   
Mutations in ABCC8 and KCNJ11 are the commonest causes of congenital hyperinsulinism.
Cross-sectional and longitudinal relation of IGF1 and IGF-binding protein 3 with lipid metabolism   
There is no influence of baseline IGF1 or IGFBP3 serum concentration on incidentally elevated or reduced lipid levels.
Impact of trimetazidine on contrast-induced nephropathy in diabetic patients with renal dysfunction undergoing elective percutaneous coronary intervention   
Trimetazidine intake before elective PCI is associated with decreased incidence of contrast-induced nephropathy and myocardial injury in diabetic patients with mild-to-moderate renal dysfunction.
Role of plasma superoxide generation in predicting decline in sensory and cardiac autonomic nerve function and mortality in patients with diabetes   
Oxidative stress predicts progression of peripheral and cardiac autonomic nerve dysfunction over 6 years in diabetic patients.
Potential mechanisms of subclinical diastolic dysfunction in young adults with type 2 diabetes mellitus   
Diabetes duration and aortic distensibility were associated with diastolic dysfunction in young adults with T2DM.
Safety and tolerability of linagliptin in patients with type 2 diabetes   
Linagliptin is associated with low overall risk of hypoglycemia and is weight neutral.
Glycaemic durability with dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes   
The effect of DPP-4 inhibitors on HbA1c in type 2 diabetes significantly declines during the second year of treatment.
Assessing carotid atherosclerosis, intraplaque neovascularization, and plaque ulceration in asymptomatic patients with diabetes mellitus   
Prevalence of subclinical carotid atherosclerosis in patients with DM is high.
Glycemic control after 6 days of insulin pump reservoir use with insulin lispro and insulin aspart in T1DM   
Insulin lispro is not inferior (SMBG; margin = 0.6 mmol/L [10.8 mg/dL]) to insulin aspart on Day 6 of reservoir wear.
Predictive power of waist-to-height ratio versus body mass index and waist circumference for identifying cardiometabolic risk in non-obese individuals   
Waist-to-height ratio is an appropriate index for identifying cardiometabolic risk in individuals with normal body mass index and waist circumference.
Pasma levels of the methylglyoxal in patients with newly diagnosed type 2 diabetes   
Increased plasma methylglyoxal level is associated with the elevation of HbA1c and malondialdehyde in newly diagnosed T2DM patients.
Correlation of adiponectin polymorphisms with the risk of diabetic nephropathy in patients with type 2 diabetes   
Adiponectin rs2241766T/G and rs17300593G/A but not rs1501299G/T and rs266729C/G polymorphisms are associated with the risk of diabetic nephropathy in T2DM, especially in the Caucasian population.
Effect of six versus two meals a day on body weight, hepatic fat content insulin resistance and beta cell function of T2DM patients   
Eating two larger meals a day (breakfast and lunch) is more effective than six smaller meals in a reduced-energy regimen for patients with type 2 diabetes.
Correlation between dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men   
Potential renal acid load and net endogenous acid production are not associated with insulin sensitivity or beta cell function.
Gut microbiota at the onset of type 1 diabetes in young children   
Non-diabetic children have a more balanced microbiota, primarily comprising of butyrate-producing species.
Correlation between heart failure and risk of diabetes   
Severity of heart failure is associated with a stepwise increased risk of developing diabetes.
Temporal sequence of the bidirectional relationship between hyperglycemia and periodontal disease   
A significant elevated risk for periodontal disease is observed among prediabetes and type 2 diabetes mellitus patients.
Biomarkers for diagnosis and prognosis of pre-diabetes and type 2 diabetes   
Serum miR-23a is a valuable biomarker for early detection of T2D and pre-diabetes with NGT.
Correlation of HOMA-IR, fasting insulin and fasting glucose with coronary heart disease mortality in nondiabetic men   
The independent risk factors for CHD mortality are insulin resistance and fasting serum insulin, but not fasting plasma glucose.
Association of tobacco smoking with impairments in glucose metabolism and insulin sensitivity/secretion   
Smoking is associated with impaired glucose regulation and a decrease in insulin sensitivity and the disposition index in first-degree relatives of type 2 diabetes subjects independently of the presence of metabolic syndrome.
Food craving post-bariatric surgery in overweight and normal weight women   
Food cravings should be anticipated post-bariatric surgery but no more so at 12 months post-surgery than by other overweight or obese individuals.
Toranomon Hospital Health Management Center Study 18 (TOPICS 18): Role of body mass index history in predicting risk of the development of hypertension   
An elevated body mass index at the baseline examination weakenes the favorable influence of a low body mass index in early adulthood on developing hypertension.
Impact of des-acyl ghrelin on glycemic control in obese diabetic   
DAG administration improves glycemic control in obese subjects with type 2 diabetes through the suppression of AG levels.
Repaglinide versus metformin monotherapy as an initial therapy in newly diagnosed type 2 diabetes mellitus patients   
Repaglinide and metformin achieve comparable efficacy in improving glycaemic control, reducing glycaemic variability, enhancing insulin sensitivity and ameliorating β-cell function.
Impact of Liraglutide on carotid intima-media thickness in patients with type 2 diabetes   
Liraglutide decreases carotid intima-media thickness from 1.19 ± 0.47 to 0.94 ± 0.21 mm in eight months.
Association between Vitamin D and 1-hour post-load plasma glucose in hypertensive patients   
There is significant and inverse relationship between 25-hydroxyvitamin D levels and glucose tolerance status, particularly with 1-h post-load glucose.
Carotid artery elasticity changes in patients with type 2 diabetes   
Arterial stiffness values provided by QAS and X-strain analysis can indicate CCA functional lesions in patients with type 2 diabetes.
Cyclophilin A in patients with type 2 diabetes , with or without coronary artery disease   
Plasma level of cyclophilin A is increased in patients with type 2 diabetes mellitus and suggests presence of vascular disease.
Visceral fat accumulation and adiponectin in clustering of metabolic abnormalities   
Measurements of the visceral fat area and adiponectin levels explains 73% of the variance in the risk clustering.
Impact of intranasal insulin on vasoreactivity and cognition in type 2 diabetes   
Intranasal insulin administration is safe and provides acute improvements of cognitive function in T2DM patients.
Influence of metformin on levels of a new cardiovascular marker, fibulin-1, in patients with type 2 diabetes   
Metformin, but not rosiglitazone, attenuates the increasing plasma levels of fibulin-1, in T2DM patients.
Association between liraglutide-induced change in body composition and modifications in levels of plasma cardiac natriuretic peptides in obese type 2 diabetic patients   
liraglutide treatment for 12-week significantly reduces body weight, waist circumference, total fat and lean mass, fat percentage, SAT and VAT areas from baseline.
Relationship between maternal parity, fetal and childhood growth, and cardiometabolic risk factors   
Offspring from nulliparous mothers have lower fetal but higher infant growth rates and higher risks of childhood overweight and adverse metabolic profile.
Relationship between BMI and acute and long-term outcome in patients presenting within 12 hours of ST-segment myocardial infarction   
BMI can no longer predict acute or long-term mortality after STEMI, after adjusting for covariates.
Changes in physical activity during a weight loss intervention   
A significant difference in weight loss between the groups at 12 months is observed, favouring the CP group. This statistical difference is not maintained at 24 months.
Prevalence of atherogenic dyslipidemia and the lipid triad in the working population and its associated variables   
After adjusting for alcohol and obesity, atherogenic dyslipidemia is significantly correlated with cardiovascular risk.
Role of growth differentiation factor-15 levels in predicting diabetic cardiomyopathy in asymptomatic T2DM patients   
GDF-15 represents a useful and novel tool to screen diabetic cardiomyopathy in patients with T2DM.
Relation of IGF1 and IGF-binding protein 3 with lipid metabolism   
IGF1 and IGFBP3 are risk marker rather than risk factors for alterations in lipid metabolism.
Comparative study of acromegalic patients with and without type 2 diabetes   
Therapy of acromegalic patients exacerbated by concomitant type 2 diabetes requires higher pegvisomant doses to normalise IGF1 levels.
Correlation of HDL-C and apolipoprotein A-I with the risk of type 2 diabetes in subjects with impaired fasting glucose   
Higher HA ratio is associated with favorable metabolic profiles and a lower risk of T2D development in subjects with IFG.
Improvement in glycaemia with lixisenatide administered before breakfast or the main meal of the day   
Lixisenatide administered before the main meal was noninferior to that administered before breakfast in patients insufficiently controlled on metformin.
Risk of urinary tract infections in subjects with newly diagnosed type 2 diabetes   
T2DM patients are more likely to experience a UTI and recurrent UTIs than subjects without T2DM.
Role of serum glycated albumin in predicting progression of diabetic retinopathy   
Presence of DR at baseline, poor glycemic control, glycated albumin, and impaired renal function predict DR progression in T2DM patients.
The Coronary Artery Calcification in Type 1 Diabetes Study: Predicting vascular complications in T1DM adults   
ABC goal achievement at baseline strongly predicts microvascular but not macrovascular complications in T1DM adults.
Circulating endothelial progenitor cells in acute myocardial infarction patients with diabetes or pre-diabetes   
There is a progressive decrease in endothelial progenitor cells levels, from pre-diabetes to DM, in AMI patients.
REPAIR-T1D: Sitagliptin and lansoprazole combination therapy in patients with recent-onset type 1 diabetes   
For the treatment group the mean change in C-peptide area under curve is −229 pmol/L (95% CI −316 to −142) at 12 months versus −253 pmol/L (−383 to −123) for the placebo group, the difference between the two groups being non-significant (p=0•77).
Empagliflozin versus glimepiride as add-on to metformin in T2DM patients   
Empagliflozin might be an effective and a well tolerated second-line treatment option for T2DM patients inadequately controlled on metformin.
Overnight glucose control with home use of closed-loop insulin delivery in adults with type 1 diabetes   
Unsupervised overnight closed-loop insulin delivery at home can improve glucose control in T1DM adults.
HERO study: Impact of laparoscopic adjustable gastric banding on control of T2DM   
Greater % weight loss, not using insulin therapy, and shorter disease duration predict increased likelihood of target control of T2D, 1 year after implantation of the laparoscopic adjustable gastric band.
Safety and efficacy of two 11β-HSD1 inhibitors T2DM patients on metformin   
High dose RO-151 is associated with slight metabolic improvements.
Cardiovascular safety of incretin-based drugs+metformin versus metformin+sulphonylurea in T2DM patients   
Combination of incretin-based drugs with metformin are safe compared with conventional combinations of glucose-lowering therapy.
Metabolic syndrome in children  
The Harmonious Efficacy of Albiglutide as an Add-On therapy or Monotherapy for an Individualized T2DM Management  
Canagliflozin: The Blockbuster drug for the Co-morbid T2DM treatment  
Dapagliflozin: Clinical perspective   
Treatment and management of diabetic macular edema   
Gestational diabetes mellitus   
From trivial to extremely vital - The resurrection of Metabolic Syndrome for the present Diabetes management  
Lifestyle counseling in routine patient care  
  More..     
 

     

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Phase IIa trial of oral insulin capsule, ORMD 0801: Oramed seeks US FDA approval to begin the trial    
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EASD - European Association for the Study of Diabetes, 2014
Sep 15, 2014 - Sep 19, 2014.
Vienna, Austria


    

 


 
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