Aug 20, 2014
             
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      Updated: Aug 20, 2014 
Secondary analysis of the Look AHEAD: Long-term effects of behavioural weight loss interventions on nephropathy in overweight or obese T2DM adults   
Weight loss should be considered as an adjunct to medical treatments in order to prevent or delay progression of CKD.
EPIC-InterAct case-cohort study: Association between saturated fatty acids and type 2 diabetes   
Association of different individual plasma phospholipid saturated fatty acids (SFA) with incident type 2 diabetes in opposite directions suggest that SFAs are not homogeneous in their effects.
Metabolic control or the burden of associated complications in diabetes among young adults   
Metabolic control was poor in patients with young-onset diabetes, when compared to patients with late-onset diabetes.
REPAIR-T1D: Combination therapy with sitagliptin and lansoprazole in patients with recent-onset type 1 diabetes   
Mean change in C-peptide area under curve for the treatment group and the placebo group is −229 pmol/L (95% CI −316 to −142) and −253 pmol/L (−383 to −123) respectively, difference being non-significant (p=0•77).
Effects of six-month exercise intervention on exercise capacity, autonomic and myocardial function in subclinical diabetic heart disease   
Exercise intolerance of subclinical diabetic heart disease was amenable to improvement by exercise training.
     
Correlation between apolipoprotein CIII concentrations and microalbuminuria in patients with type 2 diabetes   
There exists an independent positive correlation exists between the levels of apolipoprotein CIII and microalbuminuria in patients with type 2 diabetes.
Benefits of conventional insulin vs insulin infusion therapy in acute coronary syndrome patients with diabetes   
There is no real benefit in terms of GLUCV when routinely managing blood glucose by insulin infusion therapy in T2DM ACS hospitalized patients with respect to conventional insulin treatment.
Mechanism explaining normal glucose tolerance among obese individuals   
The novel biomarkers in adipose tissue that are associated with type 2 diabetes in obese individuals are ACAT1, ACACA, ALDH6A1 and MTHFD1.
Superior effects of interval vs continuous training on glycaemic control in type 2 diabetics   
When compared with energy expenditure-matched continuous walking training, interval walking training maintains insulin secretion and improves insulin sensitivity and disposition index.
Effect of metformin on atrial fibrillation in patients with type 2 diabetes mellitus   
Metformin decreases risk of AF in T2DM patients not on other anti-diabetic medication, probably via attenuation of atrial cell tachycardia-induced myolysis and oxidative stress.
Effects of a 3-month lifestyle intervention program on right ventricle free wall mechanics in patients with metabolic syndrome without type-2 diabetes   
MetS is associated with subtle impairments in both RV free wall diastolic and systolic myocardial function which may be partially related to central-obesity induced changes in pro- and anti-inflammatory cytokines and left ventricular remodeling.
Effects of dietary calcium and magnesium intakes on cardiovascular disease risks in older patients with diabetes   
High or low calcium intake increases cardiovascular disease risks in older patients with type 2 diabetes.
Exenatide twice daily versus long-acting insulin analogs in with type 2 diabetes   
Veterans treated with exenatide BID have significantly greater reduction in HbA1c and BMI than patients treated with LAIA.
GLP-1 analogues versus sitagliptin in patients with type 2 diabetes   
Compared to sitagliptin, GLP-1 analogues more effectively controlled glycemia and weight loss.
EDGE study: Impact of dipeptidyl peptidase 4 and alpha glucosidase inhibitor on endothelial dysfunction in patients with type 2 diabetes   
DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes.
Impact of sitagliptin on triglyceride-rich lipoprotein kinetics in T2DM patients   
Sitagliptin treatment for 6 weeks led to reduction in TG-rich apoB-containing lipoprotein levels by reducing the synthesis of these particles.
Impact of pioglitazone on arterial stiffness with cardio-ankle vascular index in T2DM patients on metformin   
Pioglitazone improves the cardio-ankle vascular index in T2DM patients treated with metformin.
Correlation between hypertension and genetic variability of ACE and RGS2 genes in patients with type 1 diabetes   
Clinical but not genetic risk factors seemed to be connected with BP disturbances in young T1DM patients.
Impact of common polymorphisms in MIR146a, MIR128a and MIR27a genes on neuropathy susceptibility in type 2 diabetes   
This study for the first time demonstrated the associations of MIR128a and MIR146a SNPs with DPN susceptibility and of MIR146a and MIR27a SNPs with CAN susceptibility.
Effect of sitagliptin on lipid profile in T2DM patients   
Sitagliptin significantly decreases total cholesterol , LDL-C and non-HDL-C.
Increasing metformin dose versus adding sitagliptin in T2DM patients inadequately controlled on metformin 500 mg/day   
Metformin reduces circulating malondialdehyde-modified low-density lipoprotein in type 2 diabetes mellitus.
Effects of obesity, insulin resistance, and diabetes mellitus on human myocardium before the onset of cardiomyopathy   
Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients.
Genetics of Lipid-Lowering Drugs and Diet Network Study: Epigenome-Wide Association Study of Fasting Blood Lipids   
CPT1A methylation is strongly and robustly associated with fasting very-low low-density lipoprotein cholesterol and TG.
Italian Diabetes Exercise Study (IDES): Impact of supervised exercise training on musculoskeletal symptoms and function in T2DM patients   
Preliminary evaluation of musculoskeletal symptoms is useful in favoring compliance with supervised training programs and obtaining significant benefits to the functional status of the involved joints.
MOdaliTy of Insulin treatment eValuation (MOTIV) registry sub-analysis: Duration of diabetes and effectiveness of insulin in the management of insulin-naïve patients uncontrolled on oral antidiabetic drugs   
Early administration of insulin confers better glycemic control with less insulin dosage and lower frequency of hypoglycemic events.
Correlations between A1c, fasting glucose, 2h postload glucose, and β-cell function   
HbA1c can be used as a marker to identify subjects with impaired β-cell function, but OGTT performs better than HbA1c.
NHANES-III: Prognostic value of fasting versus nonfasting low-density lipoprotein cholesterol levels   
Nonfasting LDL-cholesterol has prognostic value similar to that of fasting LDL-cholesterol.
Role of vitamin D deficiency in abnormal glycemic regulation during pregnancy   
Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus.
Disproportional proinsulinemia in the pre-diabetic state   
Disproportionately elevated proinsulinemia is observed at modestly elevated glucose levels within the normoglycemic range.
Stage of change and motivation to lifestyle changes to healthy diet and habitual physical activity in type 2 diabetes   
Changing lifestyle, particularly in the area of habitual physical activity, is not an essential part of treatment in many subjects with T2DM.
Alpha- and beta-cell abnormalities in prediabetes and type 2 diabetes defined by haemoglobin A1c   
A negative association of HbA1c with insulinogenic index, disposition index, and incretin effect is revealed.
Effect of genetic variant of the renin-angiotensin system and prevalence of type 2 diabetes mellitus on aldosterone synthase   
A genetic variant of the RAS should have a modest but significant impact on the onset of type 2 diabetes mellitus.
Serum biomarker of coronary artery calcification in type 2 diabetes   
Osteoprotegerin is a better serum biomarker of coronary artery calcification scores than osteocalcin in type 2 diabetes.
Renin–angiotensin–aldosterone–blockade and use of antidepressant therapy in T1DM patients with diabetic nephropathy   
Use of RAAS-modifying medication may improve mood in patients with type 1 diabetes and established diabetic nephropathy.
Baroreflex sensitivity changes in subjects with different glycemic statuses, including normal glucose tolerance, isolated impaired fasting glucose, impaired glucose tolerance and newly diagnosed diabetes   
Newly diagnosed diabetes and impaired glucose tolerance subjects have an impaired baroreflex sensitivity as compared to subjects with normal glucose tolerance.
Effect of diabetes on the glycogen content in the retinal pigment epithelium   
Glycogen storage is increased in the retinal pigment epithelium of diabetic patients and is associated with an increase in glycogen synthase activity.
Atherosclerotic coronary plaque in subjects with diabetic neuropathy   
Patients with charcot neuroarthropathy have a higher prevalence of severe coronary plaques compared to patients with diabetic neuropathy.
Impact of glucose and blood pressure control on diabetic kidney disease in old T2DM patients   
Adequate glucose and blood pressure control does not reduce the risk of ESRD but may delay onset of clinical albuminuria and eGFR decline in younger patients with type 2 diabetes.
Correlation between brachial-ankle pulse wave velocity and cardiac autonomic neuropathy in patients with type 2 diabetes   
Increased brachial-ankle pulse wave velocity is significantly correlated with cardiac autonomic neuropathy in patients with type 2 diabetes.
Association of body weight, weight gain and hyperglycaemia with hypertensive disorders of pregnancy in women with gestational diabetes   
The factor that has strongest impact on pregnancy-related hypertensive disorders is prepregnancy body weight.
Exenatide twice daily and long-acting insulin analogs in a veterans with type 2 diabetes   
Veterans treated with exenatide BID have significantly greater reduction in HbA1c and BMI compared with patients treated with LAIA patients.
Correlation between baseline osteocalcin levels and incident diabetes in high-risk individuals   
Lower levels of circulating osteocalcin do not predict future diabetes development.
Efficacy and safety of ipragliflozin in patients with type 2 diabetes mellitus   
Once-daily administration of ipragliflozin is dose-dependently effective in controlling glycemia without major adverse effects.
Macrophage stimulating agent soluble yeast β-1,3/1,6-glucan for topically treating diabetic foot and leg ulcers   
Local treatment of diabetic lower extremity ulcers with β-1,3/1,6-polyglucose shows good safety results.
Nateglinide + vildagliptin combination therapy versus switching to vildagliptin in type 2 diabetes patients inadequately controlled with nateglinide   
Vildagliptin and nateglinide combination therapy is effective and safe in T2DM patients.
Physical activity and dietary intake to achieve optimal metabolic control in older patients with type 2 diabetes   
Moderate physical activity and adequate dietary protein intake might be the optimal recommendation for better metabolic control in older T2DM patients.
Risk of hospitalization for diabetic macrovascular complications and in-hospital mortality with irregular physician visits   
Irregular visit group has significantly higher risks of hospitalization for IHD and stroke among diabetic patients.
PREVEND study: Association of circulating peroxiredoxin 4 and type 2 diabetes risk   
Elevated serum Prx4 levels are associated with a higher risk of incident type 2 diabetes.
Correlation between type 2 diabetes susceptibility gene variants and adult-onset autoimmune diabetes   
Latent autoimmune diabetes in adults and adult-onset type 1 diabetes share genetic risk variants with type 2 diabetes.
Impact of TCF7L2 gene variants on the therapeutic response to linagliptin   
Linagliptin significantly improves hyperglycaemia in T2DM patients both with and without the TCF7L2 gene diabetes risk alleles.
Association of preoperative left ventricular function with insulin sensitivity during cardiac surgery   
Poor preoperative left ventricular function is associated with reduced insulin sensitivity before the onset of cardiopulmonary bypass in cardiac surgery.
Predicting Model using Hemoglobin A1C to determine the time interval from pre-diabetes progressing to diabetes   
This prediction model is very useful to help prioritize the diagnosis at an early stage for targeting individuals with risk of diabetes.
Impact of calcium–vitamin D co-supplementation on glycaemic control, inflammation and oxidative stress in gestational diabetes   
Calcium plus vitamin D supplementation in women with GDM had beneficial effects on their metabolic profile.
Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in T2DM patients   
Whey protein may represent a novel approach for enhancing glucose-lowering strategies in type 2 diabetes.
ELEGANT: Treatment strategy for a T2DM patient who show pronounced weight gain after the introduction of insulin treatment   
Liraglutide reverses pronounced insulin-associated weight gain, improves glycaemic control and decreases insulin dose in T2DM patients.
Correlation between lipopolysaccharide binding protein, obesity status and incidence of metabolic syndrome among middle-aged and older individuals   
Elevated plasma lipopolysaccharide binding protein is associated with an increased risk of developing MetS among middle-aged and older individuals, especially among those with normal-weight.
Association of genetic predisposition to obesity with risk of type 2 diabetes   
Genetic predisposition to obesity leads to increased risk of type 2 diabetes, independent of BMI.
Post-breakfast closed-loop glucose control with a carbohydrate-matching bolus versus a weight-dependent bolus   
Post-breakfast closed-loop glucose control is improved when accompanied with carbohydrate-matching bolus compared to weight-dependent bolus.
Impact of adipose tissue distribution on maximum lipid oxidation rate during exercise in normal-weight women   
There is a negative association of total and abdominal fat mass measurements with exercise intensity and maximum lipid oxidation rate.
Efficacy of bedtime nutritional strategies in preventing nocturnal hypoglycaemia in T1DM patients   
Bedtime snack cannot be recommended systematically but it might be useful if prescribed in an individualized fashion.
Metabolic syndrome in children  
The Harmonious Efficacy of Albiglutide as an Add-On therapy or Monotherapy for an Individualized T2DM Management  
Canagliflozin: The Blockbuster drug for the Co-morbid T2DM treatment  
Dapagliflozin: Clinical perspective   
Treatment and management of diabetic macular edema   
Gestational diabetes mellitus   
From trivial to extremely vital - The resurrection of Metabolic Syndrome for the present Diabetes management  
Lifestyle counseling in routine patient care  
  More..     
 

     

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EASD - European Association for the Study of Diabetes, 2014
Sep 15, 2014 - Sep 19, 2014.
Vienna, Austria


    

 


 
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