Dec 19, 2014
             
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      Updated: Dec 19, 2014 
Cardiovascular autonomic neuropathy: An independent risk factor for CVD in T1DM patients   
Cardiovascular autonomic neuropathy is associated with the presence of other chronic complications in patients with type 1 diabetes.
Outcomes of insulin degludec administration on nocturnal hypoglycaemia and insulin dose in type 1 diabetic patients   
Basal-bolus treatment with insulin degludec is superior to long-acting insulin analogues detemir and glargine in reducing the rate of nocturnal hypoglycaemia.
Impact of nutritional advices associated with physical activity on glycemic control, serum TC, redox and inflammatory status in T2DM patients   
Lifestyle advice follow-up improve glycemic control, redox and inflammatory status in patients with type 2 diabetes.
     
Strength of clustering of metabolic risk factors in a parent-offspring relationship   
Mother's MetS strongly relates with daughter's MetS, but inconsistently correlates with son's MetS, but father's MetS and offspring's Mets are not correlated.
Association of glycemic variability with diabetic peripheral neuropathy in type 2 diabetes with well-controlled HbA1c   
There exists a close relationship between glycemic variability evaluated by MAGE and DPN in type 2 diabetes with well-controlled HbA1c.
Role of milder hyperglycemic states such as prediabetes on CAD   
Individuals with prediabetes identified by HbA1c undergoing coronary angiography have worse cardiometabolic profile than those identified by fasting glucose.
Fenofibrate Intervention and Event Lowering in Diabetes study   
Higher baseline plasma FGF21 levels are associated with higher risk of cardiovascular events in patients with type 2 diabetes.
Association of Insulin-like growth factor-I and insulin-like growth factor binding protein-1 to cardiovascular disease biomarkers in obese adolescents   
IGF-I and IGFBP-1 are associated with CVD risk markers and may add to clinical assessments of cardiometabolic dysfunction in youth.
Relationship between body mass index and bleeding after percutaneous coronary intervention   
BMI is associated with increased risk of bleeding and mortality after PCI.
Co-relation between glycated Hhemoglobin A1c, coronary artery calcification and insulin resistance in non-diabetic males   
Not only glucose status represented by HbA1c but also insulin resistance may be associated with CAC in non-diabetic men.
HARMONY 1 trial: Efficacy and safety of once-weekly albiglutide in patients with type 2 diabetes mellitus not controlled on pioglitazone, with or without metformin   
Albiglutide 30 mg administered once weekly as an add-on to pioglitazone (with or without metformin) leads to effective and durable glucose lowering.
Glucose control with basal-bolus regimen of insulin detemir plus insulin aspart and thrice-daily biphasic insulin aspart 30 in insulin-naive T2dm patients   
Insulin initiation and intensification using IDet+IAsp is not inferior to BIAsp1-2-3 in insulin-naive T2DM patients uncontrolled by OGLDs.
Impact of elevated body mass on systemic metabolite profile in early adulthood   
Mendelian randomization indicates causal adverse effects of increased adiposity with multiple cardiometabolic risk markers across the metabolite profile in adolescents and young adults in the non-obese weight range.
Long-term efficacy of alogliptin versus glipizide in combination with metformin in inadequately controlled T2DM patients   
Alogliptin efficacy was sustained over 2 years in patients with inadequate glycaemic control on metformin alone.
Correlation between dipeptidyl-peptidase-4 inhibitors and pancreatic cancer   
There is no higher short-term pancreatic cancer risk with DPP-4 inhibitor treatment relative to SU or TZD treatment.
Impact of sitagliptin on triglyceride-rich lipoprotein kinetics in T2DM patients   
Sitagliptin administration for a period of 6 weeks reduces triglyceride-rich apoB-containing lipoprotein levels by reducing the synthesis of these particles.
Characterizing type 2 diabetes non-remission status after bariatric surgery   
Smaller rises in levels of adiponectin characterize type 2 diabetes non-remission up to 2 years after bariatric surgery.
Betaine and Trimethylamine-N-Oxide: Predictive ability of cardiovascular outcomes in diabetes mellitus   
Elevated plasma betaine concentration serve as a marker of cardiovascular risk in diabetes.
Risk of CVD associated with dipeptidyl peptidase-4 inhibitors in T2DM patients with and without baseline CVD   
Dipeptidyl peptidase-4 inhibitors do not increase the risk of cardiovascular events in type 2 diabetes.
Postprandial glycemia with different bolus insulins   
Extended insulin boluses cannot control postprandial glycemia as well as a standard bolus in children and adults using insulin pump therapy.
Predicting effects of blood pressure lowering treatment on major cardiovascular events among individual patients with T2DM   
A multivariable treatment algorithm can identify individuals who benefit most from blood pressure–lowering therapy in terms of ARR of major adverse cardiovascular events.
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Impact of type of sweet snack of an energy-restricted diet on metabolic improvements associated with body weight loss   
18-week ERD that includes either DC or NC sweet snack and sugar-free beverage leads to loss of equivalent amounts of BW and improvement in BP measurements and glucose and insulin concentrations in overweight/obese premenopausal women.
Relationship of circulating aldosterone and natriuretic peptides with cardiorenal and metabolic disease in general community
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Aldosterone is associated with hypertension, chronic kidney disease, obesity, metabolic syndrome, concentric left ventricular hypertrophy, and lower NPs in the general community.
Early CV prevention in diabetics with mild CKD by GFR criteria alone
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Plasma lipoprotein(a) levels are associated with mild renal impairment in type 2 diabetics independent of albuminuria.
Correlation between habitual daytime napping and metabolic syndrome   
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Daytime napping is associated with an increased prevalence of metabolic syndrome in middle-aged non-obese women.
Is pre-diabetes in overweight youth associated with early atherogenic risk   
Overweight adolescents with pre-diabetes have an atherogenic lipoprotein profile of small LDL and HDL size and increased concentrations of small LDL, which is moderated by insulin resistance and visceral adiposity.
Glycemic variability and postprandial glucose contribution to HbA1c in obese subjects across the glycemic continuum from normal glycemia to first time diagnosed diabetes   
HbA1c was associated with lower PPG contribution to "relative" hyperglycemia and greater glycemic variability, in overweight/obese patients.
Correlation between body mass index and the risk of all-cause mortality among patients with type 2 diabetes mellitus   
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A U-shaped association of BMI with all-cause mortality risk exists among patients with T2DM.
Association between atherogenic dyslipidemia and incident type 2 diabetes in the low-risk group for T2DM   
Apolipoprotein B and non-HDL cholesterol are more powerful predictors for incident type 2 diabetes than fasting glucose or glycated hemoglobin in subjects with normal glucose tolerance.
Correlation between arterial stiffness and insulin treatment mode in T1DM patients   
Treatment with continuous subcutaneous insulin infusion is associated with lower arterial stiffness.
Impact of amiloride on blood pressure and urine plasminogen activation in T2DM patients with treatment–resistant hypertension   
Amiloride lowers blood pressure, urine plasminogen excretion and activatio and albumin/creatinine ratio in T2DM patients with hypertension and albuminuria.
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Modifications of the homeostasis model assessment of insulin resistance index according to age   
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Age per se does not increase HOMA-IR levels, changes that might be related to higher rates of obesity and AGR in older subjects.
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Correlation of elevated 1-h post-load plasma glucose levels with inflammatory profile in subjects with normal glucose tolerance   
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Value of a 1-h OGTT glucose ≥155 mg/dl may be helpful in identifying a subset of normal glucose tolerance individuals at risk for chronic subclinical inflammation.
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Long term retrobulbar blood flow changes in diabetic retinopathy eyes   
Increase of the resistance in the retrobulbar vessels, as a part of DR, can decrease with time and may even be reversed.
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23-Gauge versus 25-Gauge vitrectomy for treatment of proliferative diabetic retinopathy   
Both gauges can be used for treatment of proliferative diabetic retinopathy with equally effectiveness.
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British Regional Heart Study: Adiposity in early, middle and later adult life and cardiometabolic risk markers in later life
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BMI in later life is the dominant influence on cardiovascular and diabetes risks in cohort of men who are thin compared to more contemporary cohorts.
Role of dietary intervention in maternal and newborn outcomes   
When compared to control diet, low GI diet is associated with less frequent insulin use and lower birth weight.
Impact of metformin on glucose homeostasis during moderate exercise   
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Metformin had a positive effect on glucose homeostasis during exercise.
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Impact of diabetes mellitus and metabolic syndrome on on-clopidogrel platelet reactivity in stable CAD patients undergoing drug-eluting stent placement   
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Both MS and T2DM were independent predictors of HCPR after clopidogrel loading dose.
Effect of weight loss rate on long-term weight management   
Rate of weight loss does not affect the proportion of weight regained within 144 weeks.
Phenotype of resistant hypertension in patients with type 2 diabetes   
In patients with T2DM, resistant hypertension is relatively more common.
Correlation between calorie intake, insulin sensitivity and β-cell compensation, in women with prior gestational diabetes mellitus   
High calorie intake is associated with worsening insulin resistance and β-cell function in hispanic women after gestational diabetes mellitus.
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ACCORD trial analysis: Effect of intensive glycaemic control on ischaemic heart disease in middle-aged T2DM patients with other cardiovascular risk factors   
Raised glucose concentration is a modifiable risk factor for ischaemic heart disease in diabetics with other cardiovascular risk factors.
Impact of islet autoimmunity on the progressive decline in β-cell function in type 2 diabetes
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Development of islet autoimmunity in T2D is associated with a significantly more rapid β-cell functional decline.
Weight-loss therapy with phentermine and topiramate extended release in T2DM patients   
Phentermine/topiramate extended release plus lifestyle modification, as a treatment approach, can effectively promote weight loss and improve glycemic control in obese/overweight T2DM patients.
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LIBRA Trial: Role of Liraglutide in preserving pancreatic β-cell function in early type 2 diabetes   
In early T2DM patients, liraglutide provides robust enhancement of β-cell function that is sustained over 48 weeks but lost upon cessation of therapy.
ACCORD-MIND MRI Trial epidemiological analysis: Effect of hypoglycemia on brain structure in T2DM patients   
T2DM treatment related hypoglycemia may not accentuate brain pathology, specifically brain atrophy or white matter abnormalities.
Cardioprotective outcomes of nicorandil in diabetic patients undergoing elective percutaneous coronary intervention
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Nicorandil decreases the incidence of PCI-related myocardial injury and improves LVEF% after 6 months, in diabetic patients undergoing elective PCI.
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Mediators of associations between body weight and mortality in older T2DM adults   
Mortality risk is elevated in normal weight participants versus overweight participants.
Pathophysiologic changes driving the risk of future type 2 diabetes mellitus with glucose intolerance in pregnancy   
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Each degree of glucose intolerance in pregnancy predicts distinct trajectories of β-cell function, insulin sensitivity, and glycemia in the first 3 years postpartum.
Impact of postchallenge hyperglycemia and low-density lipoprotein particles on risk of arterial stiffness in healthy adults
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Additive effects of both postchallenge hyperglycemia and LDL subclass particles potentiate the risk of arterial stiffness.
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ACCORD Trial: Link between diabetic retinopathy and changes in brain structure and cognition
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Diabetic retinopathy is associated with future cognitive decline in people with type 2 diabetes.
Effect of obesity on cardiovascular responses to acute psychological stress in men   
In men, moderate adiposity correlates with reduced systolic blood pressure % reactivity, total peripheral resistance, and blood pressure variability after psychological stress.
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Efficacy and safety of mirogabalin in patients with diabetic peripheral neuropathic pain
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Mirogabalin may be a promising new treatment option for patients with diabetic peripheral neuropathic pain.
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Primary Care–Based Comparative Effectiveness Trial: Collaborative care versus screening in T2DM patients with depressive symptoms   
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Collaborative care improves depressive symptoms in T2DM patients screened positive for depressive symptoms.
EDITION 2: New insulin glargine 300 units/ml versus glargine 100 units/ml in T2DM patients on oral agents and basal insulin   
Gla-300 is comparable to Gla-100 in efficacy and is associated with a lower risk of hypoglycemia during the night and at any time of the day.
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Platelet mean volume, distribution width, and count in patients with type 2 diabetes, impaired fasting glucose, and metabolic syndrome   
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T2DM subjects versus those without tend to have higher mean platelet volume and platelet distribution width values, but non-different platelet count.
Diabetes & Aging Study: Incidence of remission in adults with type 2 diabetes
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Remission of type 2 diabetes does occur without bariatric surgery, in the community settings, but it is very rare.
Metabolic syndrome in children  
The Harmonious Efficacy of Albiglutide as an Add-On therapy or Monotherapy for an Individualized T2DM Management  
Canagliflozin: The Blockbuster drug for the Co-morbid T2DM treatment  
Dapagliflozin: Clinical perspective   
Treatment and management of diabetic macular edema   
Gestational diabetes mellitus   
From trivial to extremely vital - The resurrection of Metabolic Syndrome for the present Diabetes management  
Lifestyle counseling in routine patient care  
  More..     
 

     

Fit2Me™, a Free Customized Diet and Lifestyle Support Program for T2DM patients launched by AstraZeneca    
Bayer Receives EU Approval for EYLEA® in Diabetic Macular Edema    
U.S. FDA approves INVOKAMET™ (canagliflozin/metformin HCl) for treating adults with type 2 diabetes    
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