Apr 25, 2014
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      Updated: Apr 25, 2014 
Framingham Heart Study: Correlation between circulating endothelial microparticles and cardiometabolic risk factors   
Circulating endothelial microparticles levels are associated with dyslipidaemia.
The EPIC-INTERACT Case-Cohort Study: Long-term association between dietary protein and type 2 diabetes incidence   
Individuals with high total and animal protein intake reveal modest elevated risk of type 2 diabetes.
Mediterranean Diet impacts need for diabetes drugs and remission of newly diagnosed type 2 diabetes   
LCMD versus low-fat diet in newly diagnosed T2DM patients results in greater reduction of HbA1c levels and higher rate of diabetes remission.
Impact of selective PPARγ modulator versus pioglitazone on glycemic control in patients with type 2 diabetes   
INT131 demonstrated dose-dependent reductions in HbA1c, equivalent to 45 mg pioglitazone.
Automated nocturnal predictive low glucose suspend system for determining the frequency of morning ketosis after overnight insulin suspension   
Routine measurement of blood or urine ketones during use of an automated pump suspension system using continuous glucose monitoring is not necessary.
Soluble receptor for advanced glycation end products, clinical phenotype, HLA genotype, and risk-associated single nucleotide polymorphisms (SNPs) in the AGER gene: Correlation in newly diagnosed T1DM children   
Circulating concentrations of soluble receptor for age are associated with age and AGER gene polymorphisms in T1DM children.
Risk factors for recurrence of plantar foot ulcer diabetic patients with neuropathy   
Presence of a minor lesion is the strongest predictor of ulcer recurrence.
Effect of obesity and nonobesity on grading aortic valve stenosis severity   
AVAI and ELI for the grading of stenosis in patients with obesity may lead to overestimation of true AS severity.
Prognostic value of serum free light chains on cardiovascular events in type 2 diabetes   
Elevated serum free light chains predict cardiovascular events in type 2 diabetes.
AWARD-5: Dulaglutide versus Sitagliptin in type 2 diabetes   
Dulaglutide, at both doses is associated with superior glycemic control than sitagliptin.
Effect of incretin treatment on risk of pancreatitis in patients with type 2 diabetes mellitus   
Incidence of pancreatitis among patients using incretins is low and the drugs do not increase the risk of pancreatitis.
Impact of aerobic exercise training on arterial stiffening in metabolic syndrome without overt cardiovascular disease or T2DM   
Aerobic exercise training can improve some of the pathophysiological changes associated with MetS.
Impact of pantoprazole treatment on beta cell function in diabetes mellitus   
Pantoprazole administration may correlate with increased beta cell function and may also improve HbA1c, HOMA-B, c-peptide and proinsulin levels.
Ability of anthropometric measures to predict cardiometabolic risk factors in adults with cerebral palsy   
Waist circumference provides an indication of numerous cardiometabolic risk factors in adults with cerebral palsy.
AUTONOMY: Comparison of two patient-driven approaches to initiate and titrate prandial insulin lispro in type 2 diabetes   
Prandial insulin lispro can be effectively and safely initiated, by either of the two self-titrated algorithms.
Cutaneous manifestations in diabetes mellitus   
Infective dermatologic manifestations are associated with higher HbA1C values.
Linagliptin: Anti-inflammatory effects on hemodialysis patients with diabetes   
The anti-inflammatory effects of linagliptin monotherapy indicate that it may serve as a useful glucose control strategy for HD patients with diabetes.
Prognostic value of baseline glycemic parameters on outcomes in patients receiving DPP-4 inhibitors   
HbA1c response to DPP-4 inhibitors can be modulated mainly by baseline HbA1c and fasting glucose levels.
Hydrogen sulfide levels in patients with proliferative diabetic retinopathy   
Anti-vascular endothelial growth factor may down regulate the H2S level in the vitreous body.
Effect of eplerenone on insulin action in patients with essential hypertension   
Eplerenone has neutral effects on insulin action in hypertensive, non-diabetic patients.
Impact of overweight and insulin resistance on development of hypertension   
Being overweight or obese without insulin resistance increases the risk of hypertension and blood pressure progression.
Outcomes of drug-eluting stents versus coronary artery bypass grafting in diabetic patients with multi-vessel disease   
Early mortality in diabetic patients with multivessel disease, in the DES/PCI cohort is lower while peri-procedural stroke rates are lower in PCI cohort.
Outcomes of imeglimin as add-on therapy in T2DM patients inadequately controlled on sitagliptin monotherapy   
Imeglimin has the potential to complement other oral antihyperglycemic therapies in T2DM patients.
The EPIC-INTERACT Case-Cohort Study: Long term association between dietary protein intake and incidence of type 2 diabetes   
High total and animal protein intake is associated with a modest elevated risk of type 2 diabetes.
Abnormal ankle-brachial index in CAD patients with and without diabetes mellitus   
Abnormal ABI confers an incremental risk of MACE in addition to DM and traditional CV risk factors.
The EURODIAB Prospective Complications Study: Glycemic control and all-cause mortality risk in patients with T1DM   
When compared with the reference (median HbA1c: 8.1%), patients with low (5.6%) and high (11.8%) HbA1c exhibit increased all-cause mortality, following a U-shaped association.
Correlation between adipose tissue, liver fibrosis and tissue stiffness in morbid obesity   
Subcutaneous white adipose tissue stiffness is associated with tissue fibrosis, obesity, and diabetes-related traits.
Impact of a lifestyle program on macro- and microcirculation among severely obese adolescents   
Macro- and microvascular endothelial function are preserved in adolescents with severe obesity.
A Dose-response meta-analysis of association between blood vitamin d status and metabolic syndrome in the general adult population   
Association between blood vitamin D levels and risk of metabolic syndrome are revealed in cross-sectional studies but not in longitudinal studies.
Urinary podocalyxin-positive element: noninvasive marker for the early stage of diabetic nephropathy   
Area under the curve (AUC) of urinary PCX + EL (0.966) Is higher than that of Scys C (0.857) and SCr (0.726) for discriminating nephropathy between DN patients and controls.
Prevalence of dysglycemia and the impact of obesity in young reproductive-aged women with and without PCOS.   
Among reproductive-aged women, PCOS is independently associated with a higher risk of GDM and T2DM, irrespective of body mass index.
Inflammation, innate immune cell frequency, and metabolic microrna expression during childhood obesity   
Childhood obesity is associated with changes in immune cell frequency, inflammatory environment, and regulation of metabolic gene expression.
Identifying undiagnosed diabetes using saliva   
1,5-anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control.
Correlation between small dense low-density lipoprotein-cholesterol and risk for incident coronary heart disease   
Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease.
Effect of linagliptin on T2DM patients with and without mild-to-moderate renal impairment   
Linagliptin is an effective, well-tolerated and convenient treatment in subjects with T2DM and mild or moderate RI.
Linagliptin versus glimepiride in patients with type 2 diabetes mellitus on ongoing metformin treatment   
Linagliptin reduced pp insulin, proinsulin, glucagon, and PAI-levels showing improvement in in pp alpha and beta cell function.
Effects of cardiac rehabilitation on exercise capacity in non-diabetics and diabetic patients   
Both cardiac and noncardiac factors determine improvement in exercise capacity.
HARMONY 7: Albiglutide versus liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs   
Patients who received once-daily liraglutide had greater reductions in HbA1c than did those who received once-weekly albiglutide.
Impact of two-step addition of miglitol and mitiglinide to basal insulin therapy on fasting and postprandial glycemic contro   
The two-step addition of postprandial hypoglycemic agents to basal insulin therapy effectively decreases both the fasting and postprandial glucose levels.
Relationship between physical activity, salivary cortisol, and metabolic syndrome score in girls   
MetSyn score and many of its components are not related to cortisol salivary levels even after adjustments in physical activity, body fat percentage, and sexual maturity.
PioRAGE: Effects of pioglitazone versus glimepiride on plasma soluble RAGE and RAGE expression in type 2 diabetes   
Pioglitazone suppresses RAGE expression and increases circulating sRAGE/esRAGE.
Comparative outcomes of Insulin lispro low mixture twice daily vs basal insulin glargine once daily and prandial insulin lispro once in T2DM patients requiring insulin intensification   
In T2DM patients inadequately controlled on once-daily basal insulin glargine and metformin and/or pioglitazone, intensification with LM25 reduces HbA1c without any increase in hypoglycemia.
FADOI-DIAMOND study: Impact of educational intervention on the management of hospitalized type 2 diabetic patients   
One-shot educational intervention improves the management of hospitalized patients with type 2 diabetes and significantly improves glycemic control.
Body weight, fat distribution and weight change in hypertensives of various ethnic population   
Genetic factors or unidentified other determinants are involved in ethnic differences in the incidence of hypertension.
AGT and the GNB3 polymorphisms and insulin resistance in prehypertension   
There is no correlation between specific SNPs, blood pressure and insulin resistance.
TITANIC XV: Bioactive Titanium Stents versus Everolimus-eluting Stents in Diabetic Patients   
Everolimus-eluting stent is superior to titanium stent for clinical and angiographic end points.
Correlation between peripheral arterial disease and other atherosclerosis markers and diabetic nephropathy   
Triglycerides levels are associated with diabetic nephropathy, independently of the presence of PAD.
Small dense low-density lipoprotein as a potential risk factor of nephropathy in type 2 diabetes mellitus   
Small dense LDL is correlated with the incidence and severity of diabetic nephropathy in T2DM patients.
Correlation between body mass index and retinopathy in patients with type 1 diabetes   
BMI in correlation with HbA1c, cholesterol, and hypertension is correlated to DR progression in T1DM patients without nephropathy.
Blood glucose stabilizing effects of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes   
GIP counteracts insulin-induced hypoglycemia, most likely through a predominant glucagonotropic effect among patients with T2DM.
Effects prediabetes on arterial thickness and stiffness in obese youth   
Prediabetic youth have worse cardiometabolic risk factors, evidence of increased arterial thickness and stiffness.
Impact of colesevelam HCL monotherapy on lipoprotein particle subclasses in patients with type 2 diabetes mellitus   
In T2DM patients, colesevelam monotherapy brings about general favorable changes in certain lipoprotein subclass profiles when compared with placebo.
Gliclazide, Metformin and Pioglitazone Monotherapies in Patients with Newly Diagnosed Uncontrolled Type 2 Diabetes Mellitus   
All three drugs are effective and safe first-line pharmacological treatment options in newly diagnosed uncontrolled type 2 diabetes mellitus.
Efficacy of dapagliflozin when used in combination with hypoglycaemic drugs in type 2 diabetes mellitus   
Dapagliflozin when used as an add-on drug to conventional antidiabetic drugs improves glycaemic control in T2DM patients without significant weight gain.
Outcomes of luseogliflozin monotherapy in patients with type 2 diabetes mellitus   
Luseogliflozin administered as monotherapy for 24 weeks reduces HbA1c ,FPG, PPG, body weight, and abdominal circumference.
Frequency and predictors of intensive statin therapy use after AMI among patients with diabetes mellitus   
Only 1 in 5 diabetic patients after an AMI are prescribed intensive statin therapy at discharge.
Glucagon and epinephrine responses to hypoglycemia in youth with less than 1 yr duration of T1DM   
Blunted glucagon but not epinephrine responses to hypoglycemia in young patients with recent onset of T1DM.
Outcomes of a single autologous cord blood infusion on beta-cell and immune function in children with newly diagnosed T1DM   
After the onset of disease, an autologous cord blood infusion does not change the natural course of metabolic and immune parameters.
Early detection of T1DM with close follow-up of children with genetic risk   
FDR status and initial positivity for GADA, IA-2, and IAA or a combination of GADA and IAA are risk factors for rapid development of diabetes.
Endothelial function measured by peripheral artery tonometry among adolescents with overweight or obesity   
Endothelial dysfunction, measured by lower RH-PAT score and higher baseline pulse amplitude, is present in overweight adolescents.
The Harmonious Efficacy of Albiglutide as an Add-On therapy or Monotherapy for an Individualized T2DM Management  
Canagliflozin: The Blockbuster drug for the Co-morbid T2DM treatment  
Dapagliflozin: Clinical perspective   
Treatment and management of diabetic macular edema   
Gestational diabetes mellitus   
From trivial to extremely vital - The resurrection of Metabolic Syndrome for the present Diabetes management  
Lifestyle counseling in routine patient care  


CHMP gives positive opinions for label updates expanding indications for use of Novo Nordisk’s Tresiba® and Victoza® in adults with type 2 diabetes    
Phase IIa trial of oral insulin capsule, ORMD 0801: Oramed seeks US FDA approval to begin the trial    
Lucentis of Novartis approved in Japan for treating diabetic macular edema    
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