Apr 20, 2014
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      Updated: Apr 20, 2014 
The EURODIAB Prospective Complications Study: Glycemic control and all-cause mortality risk in patients with T1DM   
When compared with the reference (median HbA1c: 8.1%), patients with low (5.6%) and high (11.8%) HbA1c exhibit increased all-cause mortality, following a U-shaped association.
Correlation between adipose tissue, liver fibrosis and tissue stiffness in morbid obesity   
Subcutaneous white adipose tissue stiffness is associated with tissue fibrosis, obesity, and diabetes-related traits.
Impact of a lifestyle program on macro- and microcirculation among severely obese adolescents   
Macro- and microvascular endothelial function are preserved in adolescents with severe obesity.
Prevalence of dysglycemia and the impact of obesity in young reproductive-aged women with and without PCOS.   
Among reproductive-aged women, PCOS is independently associated with a higher risk of GDM and T2DM, irrespective of body mass index.
Inflammation, innate immune cell frequency, and metabolic microrna expression during childhood obesity   
Childhood obesity is associated with changes in immune cell frequency, inflammatory environment, and regulation of metabolic gene expression.
Identifying undiagnosed diabetes using saliva   
1,5-anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control.
Correlation between small dense low-density lipoprotein-cholesterol and risk for incident coronary heart disease   
Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease.
Effect of linagliptin on T2DM patients with and without mild-to-moderate renal impairment   
Linagliptin is an effective, well-tolerated and convenient treatment in subjects with T2DM and mild or moderate RI.
Linagliptin versus glimepiride in patients with type 2 diabetes mellitus on ongoing metformin treatment   
Linagliptin reduced pp insulin, proinsulin, glucagon, and PAI-levels showing improvement in in pp alpha and beta cell function.
Effects of cardiac rehabilitation on exercise capacity in non-diabetics and diabetic patients   
Both cardiac and noncardiac factors determine improvement in exercise capacity.
HARMONY 7: Albiglutide versus liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs   
Patients who received once-daily liraglutide had greater reductions in HbA1c than did those who received once-weekly albiglutide.
Impact of two-step addition of miglitol and mitiglinide to basal insulin therapy on fasting and postprandial glycemic contro   
The two-step addition of postprandial hypoglycemic agents to basal insulin therapy effectively decreases both the fasting and postprandial glucose levels.
Relationship between physical activity, salivary cortisol, and metabolic syndrome score in girls   
MetSyn score and many of its components are not related to cortisol salivary levels even after adjustments in physical activity, body fat percentage, and sexual maturity.
PioRAGE: Effects of pioglitazone versus glimepiride on plasma soluble RAGE and RAGE expression in type 2 diabetes   
Pioglitazone suppresses RAGE expression and increases circulating sRAGE/esRAGE.
Comparative outcomes of Insulin lispro low mixture twice daily vs basal insulin glargine once daily and prandial insulin lispro once in T2DM patients requiring insulin intensification   
In T2DM patients inadequately controlled on once-daily basal insulin glargine and metformin and/or pioglitazone, intensification with LM25 reduces HbA1c without any increase in hypoglycemia.
FADOI-DIAMOND study: Impact of educational intervention on the management of hospitalized type 2 diabetic patients   
One-shot educational intervention improves the management of hospitalized patients with type 2 diabetes and significantly improves glycemic control.
Body weight, fat distribution and weight change in hypertensives of various ethnic population   
Genetic factors or unidentified other determinants are involved in ethnic differences in the incidence of hypertension.
AGT and the GNB3 polymorphisms and insulin resistance in prehypertension   
There is no correlation between specific SNPs, blood pressure and insulin resistance.
TITANIC XV: Bioactive Titanium Stents versus Everolimus-eluting Stents in Diabetic Patients   
Everolimus-eluting stent is superior to titanium stent for clinical and angiographic end points.
Correlation between peripheral arterial disease and other atherosclerosis markers and diabetic nephropathy   
Triglycerides levels are associated with diabetic nephropathy, independently of the presence of PAD.
Small dense low-density lipoprotein as a potential risk factor of nephropathy in type 2 diabetes mellitus   
Small dense LDL is correlated with the incidence and severity of diabetic nephropathy in T2DM patients.
Correlation between body mass index and retinopathy in patients with type 1 diabetes   
BMI in correlation with HbA1c, cholesterol, and hypertension is correlated to DR progression in T1DM patients without nephropathy.
Blood glucose stabilizing effects of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes   
GIP counteracts insulin-induced hypoglycemia, most likely through a predominant glucagonotropic effect among patients with T2DM.
Effects prediabetes on arterial thickness and stiffness in obese youth   
Prediabetic youth have worse cardiometabolic risk factors, evidence of increased arterial thickness and stiffness.
Impact of colesevelam HCL monotherapy on lipoprotein particle subclasses in patients with type 2 diabetes mellitus   
In T2DM patients, colesevelam monotherapy brings about general favorable changes in certain lipoprotein subclass profiles when compared with placebo.
Gliclazide, Metformin and Pioglitazone Monotherapies in Patients with Newly Diagnosed Uncontrolled Type 2 Diabetes Mellitus   
All three drugs are effective and safe first-line pharmacological treatment options in newly diagnosed uncontrolled type 2 diabetes mellitus.
Efficacy of dapagliflozin when used in combination with hypoglycaemic drugs in type 2 diabetes mellitus   
Dapagliflozin when used as an add-on drug to conventional antidiabetic drugs improves glycaemic control in T2DM patients without significant weight gain.
Outcomes of luseogliflozin monotherapy in patients with type 2 diabetes mellitus   
Luseogliflozin administered as monotherapy for 24 weeks reduces HbA1c ,FPG, PPG, body weight, and abdominal circumference.
Frequency and predictors of intensive statin therapy use after AMI among patients with diabetes mellitus   
Only 1 in 5 diabetic patients after an AMI are prescribed intensive statin therapy at discharge.
Glucagon and epinephrine responses to hypoglycemia in youth with less than 1 yr duration of T1DM   
Blunted glucagon but not epinephrine responses to hypoglycemia in young patients with recent onset of T1DM.
Outcomes of a single autologous cord blood infusion on beta-cell and immune function in children with newly diagnosed T1DM   
After the onset of disease, an autologous cord blood infusion does not change the natural course of metabolic and immune parameters.
Early detection of T1DM with close follow-up of children with genetic risk   
FDR status and initial positivity for GADA, IA-2, and IAA or a combination of GADA and IAA are risk factors for rapid development of diabetes.
Endothelial function measured by peripheral artery tonometry among adolescents with overweight or obesity   
Endothelial dysfunction, measured by lower RH-PAT score and higher baseline pulse amplitude, is present in overweight adolescents.
Association between depression, metabolic control, and antidepressant medication in young T1DM patients   
Adverse treatment outcome in young T1DM patients with comorbid depressive symptoms.
Relation between maternal adiposity and blood pressure in pregnancy   
Maternal adiposity is associated with higher peripheral and central blood pressures during pregnancy.
Autoimmune polyglandular syndrome in patients with type 1 diabetes mellitus   
Autoimmune thyroid disease is the commonest autoimmune disorder associated with T1DM.
Outcomes of low dose metformin in adolescents with type I diabetes mellitus   
Low-dose metformin likely improves BMI and insulin sensitivity in T1DM adolescents.
MD-Logic artificial pancreas in home setting: Impact on night glucose control   
MD-Logic artificial pancreas is an improvement over sensor-augmented pump therapy.
Association between nonalcoholic fatty liver disease and chronic kidney disease in patients with type 1 diabetes   
Nonalcoholic fatty liver disease is strongly associated with an increased incidence of chronic kidney disease.
Outcomes of angiotensin-converting enzyme inhibitors and angiotensin ii receptor blockers in patients with diabetes mellitus   
Angiotensin-converting enzyme inhibitors but not ARBs, reduce all-cause mortality, CV mortality, and major CV events in diabetic patients.
Systematic review and mixed treatment comparison of dipeptidylpeptidase-4 inhibitors in type 2 diabetes   
Efficacy and safety for DPP-4 inhibitors when used as monotherapy or combination therapy were similar in type 2 diabetes.
Plasma glucagon responses to mixed meal feedings in youth with T1DM during the first two years after diagnosis   
Prognostic role of nonalcoholic fatty liver disease on chronic kidney disease development in type 1 diabetes   
Nonalcoholic fatty liver disease is independently associated with an increased incidence of chronic kidney disease in patients with type 1 diabetes.
Association between sedentary behavior as measured by accelerometer and cardio-metabolic risk in active older adults   
In seniors, sedentary behavior is associated with an adverse metabolic effect on LDL.
Impact of glycation of apolipoprotein C1 on its CETP inhibitory property in patients with type 1 and type 2 diabetes   
In diabetics, the ability of apoC1 to inhibit CETP activity is impaired.
Association of proliferative retinopathy in type 1 diabetes and cerebral microbleeds   
Higher cerebral microbleed prevalence in PDR+ patients seems to be a part of generalized microangiopathy that may affect the skin and the brain.
Prognostic value of rest and stress echocardiography in coronary artery disease screening among patients with T2DM   
In diabetic patients presence of an extensive inducible ischemia was independently associated with a worst outcome.
Correlation between physical activity and risk of all-cause and cardiovascular disease mortality in diabetic adults   
Moderate physical activity levels are associated with better prognosis in diabetic adults.
Association of physical activity in overweight and obese pregnant women with proinflammatory cytokines and insulin response through interleukin-6   
IL-6 partially mediates the association of MVPA with insulin sensitivity and first-phase insulin response, as it is related to reduced first-phase insulin response.
Correlation between short leukocyte telomere length, endotoxemia, and severe periodontitis in diabetics   
In diabetics, leukocyte telomere length is associated with endotoxemia and diagnosis of periodontitis.
Comparison of fasting plasma insulin, as an estimate of insulin-mediated glucose disposal with values generated by HOMA-IR in nondiabetic individuals   
Calculation of HOMA-IR does not provide a better surrogate estimate of insulin action, or of its associated dyslipidemia, than measurement of FPI.
Postprandial hyperglycemia induced changes in extracellular glutaredoxin 1 in patients with abnormal glucose tolerance and healthy subjects   
Glutaredoxin 1 may be a marker of increased oxidative stress during hyperglycemia in healthy subjects and may be a risk marker of progression toward diabetes onset.
Diabetes Heart Study: Association of Genetic Risk Score With Cardiovascular Disease and Mortality   
The two simple genetic risk scores based on 13 single nucleotide polymorphisms (SNPs) and 30 SNPs, can be used for examining genetic associations for adverse outcomes in type 2 diabetics.
Effect of Salsalate treatment on advanced glycation end products level in type 2 diabetes   
Salsalate therapy reduces early but not late glycation end products.
Effects of Leptin administration on function of pancreatic β-cells in patients with lipodystrophy   
Leptin treatment for a period of 16–20-weeks did not significantly affect insulin secretion or β-cell function in leptin-deficient individuals with lipodystrophy.
Role of diabetes and hyperglycemia in left ventricular dysfunction in a community-based cohort   
Hyperglycemia has a greater impact on left ventricle function in South Asians than in Europeans.
The INTREPID Trial: Impact of statin therapy on lipoprotein subfractions, in HIV dyslipidemia   
Pitavastatin reduces remnant lipoprotein cholesterol significantly more than does pravastatin in HIV-infected subjects.
STAMPEDE trial: Intensive medical therapy + bariatric surgery is superior to intensive medical therapy alone in achieving adequate glycemic control of type 2 DM in obese or overweight patients   
Both gastric bypass and sleeve gastrectomy show similar results, though. complications are slightly higher with gastric bypass. However, the overall success seems to be numerically higher than sleeve gastrectomy.
The Harmonious Efficacy of Albiglutide as an Add-On therapy or Monotherapy for an Individualized T2DM Management  
Canagliflozin: The Blockbuster drug for the Co-morbid T2DM treatment  
Dapagliflozin: Clinical perspective   
Treatment and management of diabetic macular edema   
Gestational diabetes mellitus   
From trivial to extremely vital - The resurrection of Metabolic Syndrome for the present Diabetes management  
Lifestyle counseling in routine patient care  


CHMP gives positive opinions for label updates expanding indications for use of Novo Nordisk’s Tresiba® and Victoza® in adults with type 2 diabetes    
Phase IIa trial of oral insulin capsule, ORMD 0801: Oramed seeks US FDA approval to begin the trial    
Lucentis of Novartis approved in Japan for treating diabetic macular edema    
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